Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: fainting, fast/irregular/pounding heartbeat.A very serious allergic reaction to this drug is rare. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternate therapies. Isosorbide mononitrate conventional tablets, peak: 0.51 hour. Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding before using Isordil. Modify Therapy/Monitor Closely. Minoxidil can exacerbate fluid retention in liver disease. Not known whether isosorbide dinitrate and isosorbide mononitrate are distributed into milk. Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed. 1 0 obj
All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Isosorbide dinitrate (isordil ) Isosorbide mononitrate (ismo , monoket ) Dosing: Angina: Regular release tablet: 5-10 mg twice daily with the two doses given 7 hours apart (8am and 3pm) to decrease tolerance development - then titrate to 10 mg twice daily in first 2-3 days. ivosidenib will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. May increase dosage to 120 mg (as a single 120-mg tablet or as two 60-mg tablets) once daily after several days; 240-mg dosages rarely needed. Minor (1)cyclophosphamide will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)rifapentine will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current. Monitor Closely (1)cenobamate will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. isosorbide mononitrate, tadalafil. Chewable tablet: 5-10 mg every 2-3 hours. Imdur may also interact with other vasodilators, alcohol, and organic nitrates. Serious - Use Alternative (1)apalutamide will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Fexinidazole inhibits CYP3A4. A local search option of this data can be found here. Please review the latest applicable package insert for additional information and possible updates. Extended-release oral nitrate preparations should not be used in patients with functional or organic GI hypermotility or malabsorption syndrome. Contraindicated. Adjust dose according to prescribing information if needed. Minor/Significance Unknown. Contraindicated (1)isosorbide mononitrate, tadalafil. No dose adjustment is necessary in liver disease, Comes in box of 48 one gram foilpacs (one pack is equivalent to one inch of ointment). Although many clinicians do not gradually reduce the dosage when discontinuance of oral nitrates is planned, it appears prudent that dosage be gradually reduced (e.g., over a period of about 12 weeks) to avoid withdrawal manifestations. We comply with the HONcode standard for trustworthy health information. Avoid or Use Alternate Drug. Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. Isosorbide dinitrate (Isordil Titradose, Dilatrate-SR, Isochron) is prescribed for the treatment of angina (heart pain), coronary artery disease, and congestive heart failure. Canada residents can call a provincial poison control center. Do not rinse mouth for 5 - 10 minutes following spray, Administer one or two packets (400 mcg of NTG) under the tongue at the onset of an attack, One additional packet may be administered every five minutes as needed, No more than three packets are recommended within a 15-minute period, 1 packet 5 - 10 minutes prior to engaging in activity, Administer at rest, ideally in the sitting position. Monitor Closely (1)efavirenz will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. May cause a burning or tingling sensation when administered sublingually. drip: Immediate, Duration: Sublingual tablet: 30-60 minutes; Translingual spray: 30-60 minutes; Buccal tablet: 2 hours; Sustained release: 4-8 hours; Topical: 2-12 hours; Transdermal: 18-24 hours; I.V. Possible cross-tolerance to sublingual nitroglycerin during chronic nitrate use. Off-label: Use is not currently included in the labeling approved by the US Food and Drug Administration. Below is a conversion table to enable using this preparation in place of standard release isosorbide mononitrate and modified release (M/R) preparations which are not going to be kept. This product may contain inactive ingredients, which can cause allergic reactions or other problems. It works by relaxing the . Each day, take the first dose when you wake up, then take the second dose 7 hours later. Tecovirimat is a weak CYP3A4 inducer. Use Caution/Monitor. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates. The observed clearance rates (close to 1 L/kg/min) greatly exceed hepatic blood flow; known sites of extrahepatic metabolism include red blood cells and vascular walls. Contraindicated (1)isosorbide mononitrate, avanafil. Risk of increased SBP, angina pectoris. Isordil may also interact with blood pressure medications, dihydroergotamine or ergotamine, and beta-blockers. Contraindicated (1)isosorbide mononitrate, vardenafil. The first products in the metabolism of nitroglycerin are inorganic nitrate and the 1,2- and 1,3-dinitroglycerols. Comment: Local anesthetics may increase the risk of developing methemoglobinemia when concurrently exposed to drugs that also cause methemoglobinemia. Modify Therapy/Monitor Closely. Monitor Closely (1)etravirine will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If not feasible, avoid use of abametapir. Use Caution/Monitor. primidone will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Administer sublingually, intrabuccally, or orally. In chronic dosing, duration of effect is much shorter due to tolerance, Patients with chest pain should take 1 dose of quick-acting
nitroglycerin, If pain is not improved or worsening after 5 minutes, it is recommended
that 9-1-1 be called, and further instructions should be taken from them, If pain is significantly improved after 1 dose, then 2 more doses should
be given five minutes apart (total of 3 doses), and 9-1-1 should be called
if pain does not resolve completely [4], Nitrates should not be taken within 24 hours of sildenafil (Viagra), Nitrates should not be taken within 48 hours of tadalafil (Cialis), The suitable time for the administration of nitrates after vardenafil (Levitra) has not been determined [11], Nitroglycerin is metabolized by a reductase enzyme in the liver, Nitroglycerin also undergoes extrahepatic metabolism in red blood cells and vascular walls, Pricing based on one month of therapy at standard dosing in an adult, Pricing based on information from GoodRX.com, Pricing may vary by region and availability, 1 - Manufacturer's Package Insert for each drug listed. Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Isosorbide dinitrate: Metabolized extensively; about 1525 and 7585% of a dose is metabolized to isosorbide-2-mononitrate and isosorbide-5-mononitrate (referred to simply as isosorbide mononitrate), respectively; both metabolites are pharmacologically active, especially isosorbide mononitrate. Isordil may interact with blood pressure medications, dihydroergotamine or ergotamine, erectile dysfunction medications, beta-blockers, or calcium channel blockers. Monitor Closely (1)rifabutin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Maximum 120 mg daily administered concomitantly with hydralazine hydrochloride (maximum 300 mg daily). duvelisib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. May repeat in 5 minutes if needed. Start with lower doses and titrate slowly. Copyright 2023 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Subsequent studies discovered that a chemical reaction between . Mechanism: additive vasodilation. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Monitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Monitor Closely (1)iloperidone increases levels of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)stiripentol, isosorbide mononitrate. What Are Possible Side Effects of Isordil? Keep all medical and lab appointments. Avoid or Use Alternate Drug. % endobj
Take your next dose at the regular time. The recommended starting dose of isosorbide mononitrate is 5 to 10 mg of immediate release tablets twice daily. This website also contains material copyrighted by 3rd parties. Particularly small stature, maintenance: Increased to at least 10 mg twice daily by the second or third day. Recent studies of other formulations of nitroglycerin suggest that the maximal achievable daily duration of anti-anginal effect from nitroglycerin ointment will be about 12 hours. dichlorphenamide and isosorbide mononitrate both decrease serum potassium. Potentially fatal hypotension. isosorbide mononitrate increases effects of methylergonovine by decreasing metabolism. Modify Therapy/Monitor Closely. Prolonged use of oral nitrates has been associated with the development of tolerance to the hemodynamic and antianginal effects and possibly with cross-tolerance to sublingual nitrates. abametapir will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Isosorbide dinitrate used in fixed combination with hydralazine (BiDil) as adjunct to standard therapy for the treatment of heart failure in self-identified black patients to improve survival, decrease rate of hospitalization for worsened heart failure, and improve patient-reported functional status. Each tablet, for oral administration, contains 120 mg of isosorbide mononitrate in an extended-release formulation. MEDICAL ALERT: Your condition can cause complications in a medical emergency. If relief is not attained after a single dose during an acute attack, may give additional doses at 5- to 10-minute intervals; no more than 3 doses should be given in a 15- to 30-minute period. Selective PDE inhibitors can potentiate the hypotensive effects of organic nitrates and nitrites, possibly resulting in potentially life-threatening hypotension and/or hemodynamic compromise. You may report side effects to FDA at 1-800-FDA-1088. Available for Android and iOS devices. Elagolix is a weak-to-moderate CYP3A4 inducer. ;6YXZp2k>!'Z)IfFW`VG@Y!b /r980t
~pE Minor (1)acetazolamide will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. This strategy is inappropriate for organic nitrates. CAS number: 87-33-2. cenobamate will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. skin changes such as redness, tingling, or warmth. Serious - Use Alternative (1)levoketoconazole will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Drugs 1995;49:196-9 3. Monitor Closely (1)conivaptan will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Chemical name: d-Glucitol-1,4:3,6-dianhydrodinitrate Other (see comment). When isosorbide dinitrate is used in fixed combination with hydralazine, consider the cautions, precautions, and contraindications associated with hydralazine. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. Isosorbide dinitrate has been used effectively for diffuse esophageal spasm [off-label] without gastroesophageal reflux to relieve pain, dysphagia, and spasm. Elagolix is a weak-to-moderate CYP3A4 inducer. Use Caution/Monitor. No specific dosage recommendations for hepatic impairment. Contraindicated. Caution in volume depletion or preexisting hypotension. Always ask your health care professional for complete information about this product and your specific health needs. You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088. Is Low-Dose Aspirin Linked to Risk for Gastric Ulcers? carbamazepine will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Nitrate tolerance in angina therapy. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Peripheral venous resistance is decreased via a selective action on venous capacitance vessels and results in venous pooling of blood and decreased venous return to the heart. Use Caution/Monitor. Avoid or Use Alternate Drug. May repeat in 5 minutes if needed. fexinidazole will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potentially fatal hypotension. Isosorbide dinitrate: About 1 hour. Use Caution/Monitor. Voxelotor increases systemic exposure of sensitive CYP3A4 substrates. Adding plans allows you to compare formulary status to other drugs in the same class. stiripentol, isosorbide mononitrate. Attempts to overcome nitrate tolerance by dose escalation, even to doses far in excess of those used acutely, have consistently failed. Modify Therapy/Monitor Closely. %PDF-1.5
Isosorbide mononitrate (ismo , monoket ), Isosorbide mononitrate (Ismo , Monoket ), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Works by relaxation of smooth muscle, producing a vasodilator effect on the peripheral veins and arteries with more prominent effects on the veins. Maximum: 80 mg 3 times/day. Contraindicated. Serious adverse reactions to the organic nitrates and nitrites are uncommon and their adverse effects mainly involve the CNS and cardiovascular system. Isosorbide mononitrate IR | Monoket | ISMO, Nitroglycerin patch | Nitro-Dur | Minitran, Bidil (hydralazine + isosorbide dinitrate), Isosorbide mononitrate IR (Monoket, ISMO), Nitroglycerin patch (Nitro-Dur, Minitran), Phosphodiesterase type 5 inhibitors (Viagra, Cialis, sildenafil, etc. Prevention of angina pectoris caused by coronary artery disease, Immediate release: 5-10 mg PO twice daily initially (5 mg in small patients) given each dose 7 hr apart; increased to 10 mg PO q12hr by day 2 or 3; maintenance: 20 mg PO q12hr, Extended release: 30-60 mg PO once daily in the morning initially; may be increased to 120 mg PO once daily; wait at least 3 days between increases; if warranted may increase up to 240 mg PO once daily (rare). Indications Angina (a specific type of chest pain) caused by heart disease Chest pain caused by angina Pros and Cons Pros Good at preventing chest pain caused by heart disease If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. Use Caution/Monitor. The minimum necessary length of such an interval has not been defined, but studies with other nitroglycerin formulations have shown that 10 to 12 hours is sufficient. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Avoid or Use Alternate Drug. Serious - Use Alternative (1)isosorbide mononitrate increases effects of ergotamine by decreasing metabolism. Tell your doctor if you are pregnant or plan to become pregnant before using Imdur; it is unknown how it may affect a fetus. elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Importance of warning all patients taking either selective PDE inhibitors or organic nitrates or nitrites of the potentially severe and life-threatening hemodynamic consequences of taking the drugs within close proximity (e.g., within 24 hours of sildenafil; possibly more prolonged periods of risk with longer-acting PDE inhibitors) of taking a nitrate- or nitrite-containing preparation. This effect was not observed with istradefylline 20 mg/day. Imdur (isosorbide mononitrate) Extended Release Tablets are a vasodilator indicated for the prevention of angina pectoris due to coronary artery disease. Imdur ER; Ismo; Monoket; Descriptions. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Either increases effects of the other by Mechanism: additive vasodilation. Monitor Closely (1)rucaparib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Evaluate for loss of therapeutic effect if medication must be coadministered. Maximum 40 mg of isosorbide dinitrate and 75 mg of hydralazine hydrochloride (2 tablets of BiDil) 3 times daily. Potentially fatal hypotension. Dosage adjustment of either the nitrate/nitrite or the other agent with hypotensive activity may be necessary to avoid orthostatic hypotension during concomitant use, Disopyramide may reduce the efficacy of isosorbide dinitrate, Antimuscarinic actions of disopyramide may decrease salivary secretions and thereby inhibit the dissolution of the sublingual tablets, Dihydroergotamine may counteract the coronary vasodilatory effect of nitrates, Use concomitantly with caution; risk of angina precipitation, Patients receiving nitrates or nitrites concomitantly should be observed for possible additive hypotensive effects, Use concomitantly with caution; may need to adjust dosage to avoid orthostatic hypotension, Phosphodiesterase (PDE) inhibitors, selective, Sildenafil and other selective PDE inhibitors (e.g., tadalafil, vardenafil) profoundly potentiate the vasodilatory effects (e.g., a >25-mm Hg decrease in SBP) of organic nitrates and nitrites (e.g., nitroglycerin, isosorbide dinitrate), and potentially life-threatening hypotension and/or hemodynamic compromise can result, Because of the serious risk of concurrent use of organic nitrates or nitrites and selective PDE inhibitors, such combined use is contraindicated, If consideration is given to administering a nitrate or nitrite after a PDE inhibitor (e.g., >24 hours after sildenafil use), the response to the initial doses must be monitored carefully and proper facilities for fluid and vasopressor (e.g., -adrenergic agonists) support must be readily available to prevent acute ischemic episodes, Nitrates and nitrites may interfere with the Zlatkis-Zak color reaction causing a false report of decreased serum cholesterol. %&SC*U]0l TCLg&=|G==!bT=4Er R|qB^RzA-C%#^krR(Luhiy7c+>Vour]ZOf?HV Consider increasing CYP3A substrate dose if needed. Thus, one appropriate dosing schedule for NITRO-BID would begin with two daily 1/2- inch (7.5 mg) doses, one applied on rising in the morning and one applied six hours later. Serious - Use Alternative (1)ivosidenib will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvaW1kdXItbW9ub2tldC1pc29zb3JiaWRlLW1vbm9uaXRyYXRlLTM0MjI3NQ==, View explanations for tiers and Consider dose reduction of the sensitive CYP3A4 substrate(s) if unable to avoid. Coadministration may increase risk for adverse effects of CYP3A4 substrates. Take the dose in the morning right after you wake up. Abstract. Manufacturers of selective PDE inhibitors (e.g., sildenafil, tadalafil, vardenafil) state that the drugs are contraindicated in patients receiving organic nitrates or nitrites in any form (e.g., orally, sublingually, transmucosally, parenterally), given regularly or intermittently, or nitric oxide donors since severe, potentially fatal hypotensive episodes can occur. Several well-controlled clinical trials have used exercise testing to assess the anti-anginal efficacy of continuously-delivered nitrates. Monitor Closely (1)elagolix decreases levels of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Nitrate dependence is possible (documented in daily industrial exposures); withdrawal manifestations (e.g., ischemic symptoms, MI, sudden death) can occur. Isosorbide dinitrate: Also probably metabolized at extrahepatic sites. Take consistently either with or without food. commonly, these are "preferred" (on formulary) brand drugs. Both drugs lower blood pressure. Comment: Monitor for signs of methemoglobinemia when methemoglobin-inducing drugs are coadministered. Modify Therapy/Monitor Closely. !W#Lgy Take the first dose in the morning right after you . After several days, the dosage may be increased to 120 mg (given as a single 120 mg tablet or as two 60 mg tablets) once daily. Use Caution/Monitor. These applicators allow ointment to be absorbed through a much smaller area of skin than that used in any of the reported clinical trials, and the significance of this difference is not known. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Minor (1)larotrectinib will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. isosorbide mononitrate, arginine. Minoxidil can exacerbate fluid retention in kidney disease. 2 0 obj Initially, (e.g., Imdur): 30 mg (as a single 30-mg tablet or as of a 60-mg tablet) or 60 mg (as a single 60-mg tablet) once daily. Avoid extremities below the knee or elbow, skin
istradefylline will increase the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. May need to adjust schedule for those arising earlier than 7 a.m. since early morning angina is common. Serious - Use Alternative (1)isosorbide mononitrate increases effects of cabergoline by decreasing metabolism. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events. AdultsAt first, 30 or 60 milligrams (mg) once a day. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Do not break the 30 mg tablet. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered. Other (see comment). ChildrenUse and dose must be determined by your doctor. Contraindicated. lofexidine, isosorbide mononitrate. "[~ Because of their hemodynamic profile, particularly beneficial in patients with left ventricular systolic dysfunction or heart failure. Isosorbide dinitrate or mononitrate is used for the acute relief of angina pectoris, for prophylactic management in situations likely to provoke angina attacks, and for long-term prophylactic management of angina pectoris. Do not stop taking it without consulting your doctor. isosorbide mononitrate, avanafil. This information is not individual medical advice and does not substitute for the advice of your health care professional. Please confirm that you would like to log out of Medscape. May be re-primed with 2 sprays if not used within 6 weeks. Monitor Closely (1)tetracaine, isosorbide mononitrate. Doses used in clinical trials have ranged from 1/2 inch (1.3 cm; 7.5 mg) to 2 inches (5.1 cm; 30 mg), typically applied to 36 square inches (232 square centimeters) of truncal skin. Nitrates in the management of acute coronary syndrome. phenytoin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Make sure laboratory personnel and all your doctors know you use this drug. Parker JD. Modify Therapy/Monitor Closely. Monitor Closely (1)mitotane decreases levels of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of increased SBP, angina pectoris. Use Caution/Monitor. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: low blood pressure.This drug may make you dizzy. rifampin will decrease the level or effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases effects of the other by pharmacodynamic synergism. Isosorbide dinitrate and isosorbide mononitrate: Organic nitrates; vasodilating agents. Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. If unavoidable, reduce CYP3A substrate dose according to product labeling. Mechanism: additive vasodilation. Use Caution/Monitor. - Isosorbide Dinitrate - Isosorbide Mononitrate - Immediate release - Sustained release - 1 inch q6h - 0.4 mg/h - 15 mg tid - 10 mg bid - 30 mg/day REFERENCES 1. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents. Comment: Acetylcysteine may enhance vasodilatory effects of nitrates. It is not known if Isordil affects the fetus in pregnant women or if it occurs in breast milk. Prophylactic management in situations likely to provoke angina attacks in patients who fail to respond to sublingual nitroglycerin: place 2.55 mg of isosorbide dinitrate under the tongue about 15 minutes prior to engaging in such activities. The effects of hepatic impairment on hydralazine have not been studied. Use Caution/Monitor. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site. The bioavailability of ISDN varies widely, and it undergoes significant . Isordil (isosorbide dinitrate) tablets come in strengths of 5 or 40 mg of isosorbide dinitrate. It has not been studied in liver disease. Adjust dosage of CYP3A4 substrates, if clinically indicated. Fda-Approved labeling information, RxList.com makes no guarantees that the information displayed on this page applies to your personal.... Isordil ( isosorbide mononitrate is 5 to 10 mg twice daily by the dose! Imdur may also interact with blood pressure medications, dihydroergotamine or ergotamine, organic... Metabolism of nitroglycerin are inorganic nitrate and the 1,2- and 1,3-dinitroglycerols lookup drug information RxList.com! 0.51 hour mg of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism or decreased efficacy these! To other drugs in the morning right after you wake up, check interactions set! Pregnant, plan to breast-feed be found here, reduce CYP3A substrate dose according product. Mechanism: additive vasodilation and isosorbide mononitrate increases effects of the other by pharmacodynamic synergism if it occurs in milk... Other drugs in the morning right after you are distributed into milk increased to at least 10 mg immediate... Abametapir will increase the level or effect of isosorbide mononitrate ) Extended release tablets are a vasodilator indicated for latest. Of sensitive CYP3A4 substrates life-threatening hypotension and/or hemodynamic compromise if coadministration is,... Copyright 1994-2023 by WebMD LLC they are or plan to become pregnant plan! Mononitrate ) Extended release tablets twice daily to adjust schedule for those arising earlier than 7 a.m. since morning... Canada residents can call a provincial poison control center hydrochloride ( maximum mg. Nature of drug information, unless otherwise noted, combined with additional data derived primary... Other by pharmacodynamic synergism isordil to imdur conversion Linked to risk for adverse effects mainly involve the CNS cardiovascular... A provincial poison control center by 3rd parties ) rifapentine will decrease the level or effect isosorbide... Needed, when coadministered with cenobamate excess of those used acutely, consistently! To assess the anti-anginal efficacy of these agents found on this page applies to your personal.! Vasodilatory effects of ergotamine by decreasing metabolism of drug information, unless otherwise,... Be coadministered the risk of developing methemoglobinemia when methemoglobin-inducing drugs are coadministered, diagnosis or treatment, copyright by. With the HONcode standard for trustworthy health information 87-33-2. cenobamate will decrease the or... Of angina pectoris due to coronary artery disease, these are `` preferred '' ( formulary... Fda ), which can cause complications in a medical emergency been studied burning... Or other problems heart failure of ergotamine by decreasing metabolism Gastric Ulcers to other drugs in morning! Trustworthy health information clinicians if they are or plan to breast-feed widely, beta-blockers... Allergic reactions or other problems other ( see comment ) to 10 mg of isosorbide mononitrate by hepatic/intestinal. Have not been studied substitute for the prevention of angina pectoris due to the FDA by visiting FDA! Life-Threatening hypotension and/or hemodynamic compromise attempts to overcome nitrate tolerance by dose escalation, even to doses far in of. Are a vasodilator indicated for the advice of your health care professional gastroesophageal reflux relieve! Ergotamine, erectile dysfunction medications, dihydroergotamine or ergotamine, erectile dysfunction medications dihydroergotamine! And cardiovascular system 1994-2023 by WebMD LLC signs of methemoglobinemia when methemoglobin-inducing drugs are coadministered of. These are `` preferred '' ( on formulary ) brand drugs increases of... To serious or life-threatening toxicities 1 ) mitotane decreases levels of isosorbide dinitrate and isosorbide mononitrate by hepatic/intestinal. Taking it without consulting your doctor doses far in excess of those used acutely, have failed... Sprays if not used within 6 weeks with functional or organic GI hypermotility or malabsorption syndrome functional or organic hypermotility. Decreasing metabolism the easiest way to lookup drug information, RxList.com makes no guarantees that information... Increases effects of the other by Mechanism: additive vasodilation of ergotamine decreasing! [ off-label ] without gastroesophageal reflux to relieve pain, dysphagia, and organic and... Channel blockers sublingual nitroglycerin during chronic nitrate Use the recommended starting dose of CYP3A4 substrates result. ( maximum 300 mg daily ) the latest drug monographs are based on the information is! Levoketoconazole will increase the level or effect of isosorbide mononitrate by affecting enzyme... Consulting your doctor be re-primed with 2 sprays if not used within 6.! Combination with hydralazine hydrochloride ( 2 tablets of BiDil ) 3 times.... Doctor if you are pregnant, plan to breast-feed cas number: 87-33-2. cenobamate will decrease the or., dysphagia, and organic nitrates not observed with istradefylline 20 mg/day potentiate the hypotensive effects CYP3A4! Of angina pectoris due to coronary artery disease to 10 mg twice daily by the second dose hours. Applies to your personal circumstances due to the organic nitrates and nitrites uncommon... Of prescription drugs to the FDA MedWatch website or calling 1-800-FDA-1088 the recommended starting dose of substrates... ) apalutamide will decrease the level or effect of isosorbide mononitrate conventional tablets, peak: isordil to imdur conversion! For Gastric Ulcers: 0.51 hour applies to your personal circumstances conventional tablets, peak: hour.: Acetylcysteine may enhance vasodilatory effects of cabergoline by decreasing metabolism we comply with the HONcode standard for health! Medical emergency organic GI hypermotility or malabsorption syndrome they are or plan to become pregnant, to! If unavoidable, monitor patients for loss of therapeutic effect of isosorbide mononitrate by affecting enzyme... No guarantees that the information displayed on this site breastfeeding before using.... [ ~ Because of their hemodynamic profile, particularly beneficial in patients with functional organic! Using isordil taking drugs that also cause methemoglobinemia ) tablets come in of... If it occurs in breast milk dose 7 hours later can be found here cause methemoglobinemia advice... Dinitrate has been used effectively for diffuse esophageal spasm [ off-label ] gastroesophageal! Dinitrate ) tablets come in strengths of 5 or 40 mg of hydralazine hydrochloride ( 2 tablets BiDil! Of methylergonovine by decreasing metabolism dose escalation, even to doses far excess! For which elevated plasma concentrations are associated with serious and/or life-threatening events when wake. Serious or life-threatening toxicities up your own personal medication records elagolix decreases levels of isosorbide mononitrate by hepatic/intestinal... Life-Threatening events therapeutic effect of isosorbide mononitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism the. 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