I think the biggest problem I currently have with tableless design is that it that it can be a problem displaying on different browsers.  Table design has already gone through these growing pains.  I rarely find an issue anymore with a browser or operating system displaying a tabled design inaccurately.  The browser code has been refined over a decade and

I am by no means an expert on layouts with tableless design, so this is based on my perspective of the sites I’ve witnessed being produced.  They all have a similar layout.  There is a banner along the top, often a set of links along the right or left, a footer, and a blank area in the middle with content.